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Global daily dynamics of the pineal transcriptome

Bustos, Diego M., Bailey, Michael J., Sugden, David, Carter, David Allan, Rath, Martin F., Møller, Morten, Coon, Stephen L., Weller, Joan L. and Klein, David C. 2011. Global daily dynamics of the pineal transcriptome. Cell and Tissue Research 344 (1) , pp. 1-11. 10.1007/s00441-010-1094-1

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Abstract

Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca2+, cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Pineal gland ; Suprachiasmatic nucleus ; Circadian rhythm ; Gene expression ; Transcriptome ; Microarray ; Systems biology
Publisher: Springer Berlin / Heidelberg
ISSN: 0302-766X
Related URLs:
Last Modified: 04 Jun 2017 03:14
URI: http://orca.cf.ac.uk/id/eprint/18694

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