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Penicillin detection with nanocrystalline-diamond field-effect sensor

Abouzar, Maryam H., Poghossian, Arshak, Razavi, Arash, Besmehn, Astrid, Bijnens, Nathalie, Williams, Oliver Aneurin, Haenen, Ken, Wagner, Patrick and Schöning, Michael J. 2008. Penicillin detection with nanocrystalline-diamond field-effect sensor. Physica Status Solidi a Applications and Materials Science 205 (9) , pp. 2141-2145. 10.1002/pssa.200879713

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Abstract

Nanocrystalline-diamond (NCD) films have been utilised for the detection of penicillin G for the first time. The developed penicillin-sensitive biosensor consists of a field-effect capacitive electrolyte-diamond-insulator-semiconductor (EDIS) structure with an immobilised enzyme layer that covers the gate region of the sensor. Undoped NCD thin films of about 100 nm thickness were grown on a p-Si-SiO2 (50 nm thermally grown SiO2) structure by microwave plasma-enhanced chemical vapour deposition. The enzyme penicillinase has been adsorptively immobilised directly onto the O-terminated NCD surface. The EDIS biosensors have been characterised in buffer solutions with different content of penicillin G by means of capacitance–voltage and constant-capacitance method. The developed penicillin biosensor possesses a low detection limit of 5 µM and a high sensitivity of 60–70 mV/decade in a wide linear range of 0.005–2.5 mM penicillin G concentration.

Item Type: Article
Status: Published
Schools: Physics and Astronomy
Subjects: Q Science > QC Physics
Publisher: Wiley
ISSN: 1862-6300
Last Modified: 04 Jun 2017 03:14
URI: http://orca.cf.ac.uk/id/eprint/18715

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