Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Novel role of regulatory T cells in limiting early neutrophil responses in skin

Richards, Hannah Catharine, Williams, Anwen Sian, Jones, Emma, Hindley, James Phillip, Godkin, Andrew James, Simon, Anna Katharina and Gallimore, Awen Myfanwy 2010. Novel role of regulatory T cells in limiting early neutrophil responses in skin. Immunology 131 (4) , pp. 583-592. 10.1111/j.1365-2567.2010.03333.x

Full text not available from this repository.

Abstract

It is clear that CD4+ CD25+ Foxp3+ regulatory T (Treg) cells inhibit chronic inflammatory responses as well as adaptive immune responses. Among the CD4+ T-cell population in the skin, at least one-fifth express Foxp3. As the skin is constantly exposed to antigenic challenge and is a common site of vaccination, understanding the role of these skin-resident Treg cells is important. Although the suppressive effect of Treg cells on T cells is well documented, less is known about the types of innate immune cells influenced by Treg cells and whether the Treg cells suppress acute innate immune responses in vivo. To address this we used a mouse melanoma cell line expressing Fas ligand (B16FasL), which induces an inflammatory response following subcutaneous injection of mice. We demonstrate that Treg cells limit this response by inhibiting neutrophil accumulation and survival within hours of tumour cell inoculation. This effect, which was associated with decreased expression of the neutrophil chemoattractants CXCL1 and CXCL2, promoted survival of the inoculated tumour cells. Overall, these data imply that Treg cells in the skin are rapidly mobilized and that this activity serves to limit the amplification of inflammatory responses at this site.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: neutrophils; regulatory T cells; skin; tumour
Publisher: Wiley Blackwell
ISSN: 0019-2805
Last Modified: 06 Oct 2018 20:27
URI: http://orca.cf.ac.uk/id/eprint/18837

Citation Data

Cited 16 times in Google Scholar. View in Google Scholar

Cited 23 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item