Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance

Brooks, Simon Philip, Fielding, Steven A., Döbrössy, Màtè, von Hörsten, Stephan and Dunnett, Stephen Bruce 2009. Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance. Brain Research Bulletin 79 (5) , pp. 310-315. 10.1016/j.brainresbull.2009.03.003

Full text not available from this repository.

Abstract

In accordance with the genetic nature of Huntington's disease (HD), transgenic and knock-in mouse models have been developed that have sought to recapitulate the key features of the human condition. To date, only a single rat model has been developed, the tgHD rat that carries 51 CAG repeats. The tgHD rat has many of the anatomical and behavioural characteristics of HD, including cognitive, emotional and motor abnormalities. To characterize this model further, hemizygous tgHD rats were tested on an operant serial implicit learning task (SILT), to determine whether these animals have an implicit learning deficit as reported in HD patients. The SILT utilises a predictable two-stage sequence of responding to two consecutive stimuli (S1 and S2) as a probe of implicit learning, embedded amongst many randomly presented two-stage sequences. The results suggest that the hemizygous tgHD rats have a mild but progressive cognitive deficit that is attentional in nature. Longitudinal responding to the S1 stimuli demonstrated deficits that progressed over time for both accuracy and reaction time measures, whereas responses to S2 stimuli were mild and stable over time. Whilst a significant effect of predictability over time was identified, analyses of the final time point alone, failed to demonstrate between group differences in their ability to utilise the predictable information at this time point, when differences between the groups should be at their most pronounced. The results suggest that the hemizygous tgHD rats have mild cognitive deficits that are attentional in nature, but no implicit learning deficit.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: operant; SILT; implicit learning; tgHD rat; Huntington's disease
Publisher: Elsevier
ISSN: 0361-9230
Last Modified: 04 Jun 2017 03:16
URI: http://orca.cf.ac.uk/id/eprint/19069

Citation Data

Cited 15 times in Google Scholar. View in Google Scholar

Cited 16 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item