White, Rhian Ellen, Dickinson, John Richard, Semple, Colin, Powell, David J. and Berry, Colin 2011. The retroviral proteinase active site and the N-terminus of Ddi1 are required for repression of protein secretion. FEBS Letters 585 (1) , pp. 139-142. 10.1016/j.febslet.2010.11.026 |
Abstract
The Ddi1 protein of the yeast Saccharomyces cerevisiae is involved in numerous interactions with the ubiquitin system, which may be mediated by its N-terminal ubiquitin like domain and its C-terminal ubiquitin associated domain. Ddi1 also contains a central region with all the features of a retroviral aspartic proteinase, which was shown to be important in cell-cycle control. Here we demonstrate an additional role for this domain, along with the N-terminal region, in protein secretion. These results further substantiate the hypothesis that Ddi1 functions in vivo as a catalytically-active aspartic proteinase.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Subjects: | Q Science > QR Microbiology R Medicine > RB Pathology |
Uncontrolled Keywords: | Saccharomyces; Ddi1; VSM1; protein secretion; proteinase; ubiquitin; aspartic |
Publisher: | Elsevier |
ISSN: | 0014-5793 |
Last Modified: | 05 Feb 2020 21:03 |
URI: | http://orca.cf.ac.uk/id/eprint/19505 |
Citation Data
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