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Mapping choroidal and retinal thickness variation in Type 2 diabetes using three-dimensional 1060-nm optical coherence tomography

Esmaeelpour Hajyar, Marieh, Povazay, Boris, Hermann, Boris, Hofer, Bernd, Kajic, Vedran, Hale, Sarah L., North, Rachel Valerie, Drexler, Wolfgang and Sheen, Nicholas John Leighton 2011. Mapping choroidal and retinal thickness variation in Type 2 diabetes using three-dimensional 1060-nm optical coherence tomography. Investigative Ophthalmology and Visual Science 52 (8) , pp. 5311-5316. 10.1167/iovs.10-6875

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Abstract

Purpose. To map choroidal (ChT) and retinal thickness (RT) in healthy subjects and patients with diabetes with and without maculopathy using three dimensional 1060-nm optical coherence tomography (3D-1060nm-OCT). Methods. Sixty-three eyes from 42 diabetic subjects (41–82 years of age; 11 females) grouped according to a custom scheme using Early Treatment Diabetic Retinopathy Study definitions for pathology within 1 disc-diameter of fovea (without pathology [NDR], microaneurysms [M1], exudates [M2], clinically significant macular edema [CSME]) and 16 eyes from 16 healthy age matched subjects (38–79 years of age; 11 females) were imaged by 3D-1060nm-OCT performed over a 36° × 36° field of view. Axial length, 45° fundus photographs, body mass index, plasma glucose, and blood pressure measurements were recorded. The ChT at the subfoveal location and ChT maps between RPE and the choroidal–scleral interface were generated and statistically analyzed. Results. RT maps show thinning in the NDR group but an increase in thickness with increasing maculopathy in the temporal and central regions (unpaired t-test; P < 0.05). ChT mapping of all diabetic patients revealed central and inferior thinning compared to healthy eyes (unpaired t-test; P < 0.001). Subfoveal ChT (mean ± SD) for healthy eyes was 327 ± 74 μm, which was significantly thicker than all diabetic groups (214 ± 55 μm for NDR, 208 ± 49 μm for M1, 205 ± 54 μm for M2, and 211 ± 76 μm for CSME (ANOVA P < 0.001; Tukey P < 0.001).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > R Medicine (General)
R Medicine > RE Ophthalmology
Additional Information: Supported in part by the Biotechnology and Biological Sciences Research Council, Cardiff University; FP6-IST-NMP-2 STREPT (017128, NanoUB); DTI Grant (OMICRON); AMR Grant (AP1110); European Union project FUN OCT (FP7 HEALTH, contract no. 201880) and Carl Zeiss Meditec Inc.; and Diabetes UK Grant BDA:RD07/003472. Confirmation received by publisher on 21 February 2014 that publisher's pdf can be self-archived 6 months after publication.
Publisher: Association for Research in Vision and Ophthalmology
ISSN: 0146-0404
Funders: BBSRC, FP6-IST-NMP-2 STREPT (017128, NanoUB, DTI Grant (OMICRON), AMR Grant (AP1110), European Union project FUN OCT (FP7 HEALTH, contract no. 201880), Carl Zeiss Meditec Inc., Diabetes UK Grant BDA:RD07/003472
Date of First Compliant Deposit: 30 March 2016
Last Modified: 06 Feb 2018 20:42
URI: http://orca.cf.ac.uk/id/eprint/19723

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