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Gene expression and behaviour in mouse models of HD

Bowles, Kathryn R., Brooks, Simon Philip, Dunnett, Stephen Bruce and Jones, Lesley 2012. Gene expression and behaviour in mouse models of HD. Brain Research Bulletin 88 (2-3) , pp. 276-284. 10.1016/j.brainresbull.2011.07.021

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Abstract

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease, resulting in expansion of the CAG repeat in exon 1 of the HTT gene. The resulting mutant huntingtin protein has been implicated in the disruption of a variety of cellular functions, including transcription. Mouse models of HD have been central to the development of our understanding of gene expression changes in this disease, and are now beginning to elucidate the relationship between gene expression and behaviour. Here, we review current mouse models of HD and their characterisation in terms of gene expression. In addition, we look at how this can inform behaviours observed in mouse models of disease. The relationship between gene expression and behaviour in mouse models of HD is important, as this will further our knowledge of disease progression and its underlying molecular events, highlight new treatment targets, and potentially provide new biomarkers for therapeutic trials.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Huntington’s disease; Gene expression; Behaviour; Mouse models; Transcription; Epigenetics
Publisher: Elsevier
ISSN: 0361-9230
Funders: Wellcome Trust studentship, CHDI Inc. Foundation
Last Modified: 04 Jun 2017 03:21
URI: http://orca.cf.ac.uk/id/eprint/20018

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