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The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder

Cohen-Woods, Sarah, Craig, Ian, Gaysina, Darya, Gray, Joanna, Gunasinghe, Cerisse, Craddock, Nicholas John, Elkin, Amanda, Jones, Lisa, Kennedy, James, King, Nicole, Korszun, Ania, Knight, Jo, Owen, Michael John, Parikh, Sagar, Strauss, John, Sterne, Abram, Tozzi, Federica, Perry, Julia, Muglia, Pierandrea, Vincent, John, McGuffin, Peter and Farmer, Anne 2010. The Bipolar Association Case-Control Study (BACCS) and meta-analysis: No association with the 5,10-Methylenetetrahydrofolate reductase gene and bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (7) , pp. 1298-1304. 10.1002/ajmg.b.31101

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Abstract

Bipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta-analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: mood disorder; bipolar disorder; manic depression; genetics; MTHFR
Publisher: Wiley-Blackwell
ISSN: 1552-4841
Last Modified: 04 Jun 2017 03:30
URI: http://orca.cf.ac.uk/id/eprint/22151

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