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A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

Thorp-Greenwood, Flora Lottie, Fernández-Moreira, Vanesa, Millet, Coralie Ode, Williams, Catrin Ffion, Cable, Joanne, Court, Jonathan B., Hayes, Anthony Joseph, Lloyd, David and Coogan, Michael Peter 2011. A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Chemical Communications 47 (11) , pp. 3096-3098. 10.1039/c1cc10141b

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Abstract

A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Chemistry
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Last Modified: 07 Nov 2017 02:36
URI: http://orca.cf.ac.uk/id/eprint/22276

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Cited 31 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 25 times in Web of Science. View in Web of Science.

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