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The genetics of anorexia nervosa collaborative study: methods and sample description

Kaye, Walter H., Bulik, Cynthia M., Plotnicov, Katherine, Thornton, Laura, Devlin, Bernie, Fichter, Manfred M., Treasure, Janet, Kaplan, Allan, Woodside, D. Blake, Johnson, Craig, Halmi, Katherine, Brandt, Harry A., Crawford, Steve, Mitchell, James E., Strober, Michael, Berrettini, Wade and Jones, Ian Richard 2008. The genetics of anorexia nervosa collaborative study: methods and sample description. International Journal of Eating Disorders 41 (4) , pp. 289-300. 10.1002/eat.20509

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Abstract

Objective: Supported by National Institute of Mental Health (NIMH), this 12-site international collaboration seeks to identify genetic variants that affect risk for anorexia nervosa (AN). Method: Four hundred families will be ascertained with two or more individuals affected with AN. The assessment battery produces a rich set of phenotypes comprising eating disorder diagnoses and psychological and personality features known to be associated with vulnerability to eating disorders. Results: We report attributes of the first 200 families, comprising 200 probands and 232 affected relatives. Conclusion: These results provide context for the genotyping of the first 200 families by the Center for Inherited Disease Research. We will analyze our first 200 families for linkage, complete recruitment of roughly 400 families, and then perform final linkage analyses on the complete cohort. DNA, genotypes, and phenotypes will form a national eating disorder repository maintained by NIMH and available to qualified investigators.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Anorexia nervosa ; Eating disorders ; Bulimia nervosa ; Psychiatric disorders ; Genetics ; Linkage analysis ; Genomics
Publisher: Wiley-Blackwell
ISSN: 0276-3478
Last Modified: 04 Jun 2017 03:32
URI: http://orca.cf.ac.uk/id/eprint/22445

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