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α-Synuclein and dopamine at the crossroads of Parkinson's disease

Venda, Lara Lourenço, Cragg, Stephanie J., Buchman, Vladimir L. and Wade-Martins, Richard 2010. α-Synuclein and dopamine at the crossroads of Parkinson's disease. Trends in Neurosciences 33 (12) , pp. 559-568. 10.1016/j.tins.2010.09.004

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Abstract

α-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinal motor symptoms are linked to death of dopaminergic neurons in the nigrostriatal pathway. Here we ask why these neurons are preferentially susceptible to neurodegeneration in PD and how α-synuclein is involved. To address these questions we bring together recent findings from genome-wide association studies, which reveal the involvement of α-synuclein gene variants in sporadic PD, with recent studies highlighting important roles for α-synuclein in synaptic transmission and dopaminergic neuron physiology. These latest advances add to our understanding of PD etiology and provide a central link between the genetic findings and neurodegeneration observed in sporadic PD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: Review
Publisher: Elsevier
ISSN: 0166-2236
Related URLs:
Last Modified: 04 Jun 2017 03:32
URI: http://orca.cf.ac.uk/id/eprint/22564

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