Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia

Edden, Richard Anthony Edward, Harris, Ashley D., Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X, Evans, Christopher John ORCID: https://orcid.org/0000-0002-6619-4245, Saxena, Neeraj ORCID: https://orcid.org/0000-0003-0913-9351, Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372, Bailey, Damian M. and Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144 2010. Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. Journal of Magnetic Resonance Imaging 32 (2) , pp. 320-325. 10.1002/jmri.22233

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Abstract

Purpose: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges. Materials and Methods: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O2), hypoxic (12% O2), and hyperoxic (40% O2) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume. Results: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia. Conclusion: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI) Physics and Astronomy
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	MRS ; Lactate ; Hypoxia ; Hyperoxia ; MEGA-PRESS
Publisher:	John Wiley & Sons
ISSN:	1053-1807
Last Modified:	05 Nov 2022 15:19
URI:	https://orca.cardiff.ac.uk/id/eprint/22885

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