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Tris(8-hydroxyquinolinato)gallium(III)-loaded copolymer micelles as cytotoxic nanoconstructs for cosolvent-free organometallic drug delivery

Collins, Andrew M., Zabkiewicz, Joanna, Ghiggi, Chiara, Hauser, Jonathan C., Burnett, Alan Kenneth and Mann, Stephen 2011. Tris(8-hydroxyquinolinato)gallium(III)-loaded copolymer micelles as cytotoxic nanoconstructs for cosolvent-free organometallic drug delivery. Small 7 (12) , pp. 1635-1640. 10.1002/smll.201100405

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Abstract

Therapeutically useful concentrations of the water-insoluble organometallic drug, tris(8-hydroxyquinolinato)gallium(III), are delivered to haematological cell lines without the need for toxic cosolvents. Delivery is by sequestration into aqueous micelles of a poly(ethylene glycol)/poly(propylene glycol)/poly(ethylene glycol) triblock copolymer using a facile method based on emulsion-mediated evaporation. The drug-loaded micelles function as a cell cycle inhibitor and cause cell death by a dose-dependent increase in apoptosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: drug delivery; nanoconstructs; copolymers; cytotoxicity; anti-cancer agents
Publisher: Wiley
ISSN: 1613-6810
Last Modified: 25 Jun 2017 03:03
URI: http://orca.cf.ac.uk/id/eprint/22961

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