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Characterization of the electrochemical behavior of gastrointestinal fluids using a multielectrode sensor probe

Twomey, K., Alvarez de Eulate, E., Marchesi, Julian Roberto, Kolida, S., Gibson, G., Arrigan, D. W. M. and Ogurtsov, V. I. 2011. Characterization of the electrochemical behavior of gastrointestinal fluids using a multielectrode sensor probe. IEEE Transactions on Biomedical Engineering 58 (9) , pp. 2521-2527. 10.1109/TBME.2011.2158543

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Abstract

A characterization of gastrointestinal fluids has been performed by means of an electrochemical sensor that has potential for clinical in vivo and in vitro monitoring applications. The sensor comprised a three-electrode cell with a counter, reference, and four working electrodes, Au, Pt, Ir, and Rh. Cyclic voltammetry was used to obtain chemical information from faecal water (in vitro) and gut model (in vivo ) fluids. Stable voltammetric responses were obtained for both fluids at these noble metal working electrodes. The responses differed in shape that demonstrated the discrimination capability and the potential for practical use as a tool for gastrointestinal fluid investigation. The analysis of the stability profiles in faecal water over a 14-h duration has indicated a possible adsorption mechanism with the formation of a biolayer on the sensor surface. The stability in gut model fluids over a 42-h duration has demonstrated a more stable profile, but the mechanisms involved are more complicated to determine.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: electrochemical; electrode; gastrointestinal fluid; voltammetry
Publisher: Institute of Electrical and Electronic Engineers
ISSN: 0018-9294
Last Modified: 04 Jun 2017 03:34
URI: http://orca.cf.ac.uk/id/eprint/23017

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