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Maternal depression and child and adolescent depression symptoms: an exploratory test for moderation by CRHR1, FKBP5 and NR3C1 gene variants

Lewis, Gemma, Collishaw, Stephan, Harold, Gordon Thomas, Rice, Frances and Thapar, Anita 2012. Maternal depression and child and adolescent depression symptoms: an exploratory test for moderation by CRHR1, FKBP5 and NR3C1 gene variants. Behavior Genetics 42 (1) , pp. 121-132. 10.1007/s10519-011-9482-1

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Abstract

This study investigated moderation of the association between recurrent maternal depression and offspring depression symptoms by a selection of biologically relevant gene variants. 271 children/adolescents (aged 9.00 to 16.00 years) whose mothers had experienced at least two episodes of DSM-IV major depression and 165 controls (aged 12.25 to 16.67 years) drawn from a population-based twin register were used. Seven single nucleotide polymorphisms (SNPs) from three genes were genotyped in children. The genes were the Corticotropin Receptor Type 1 gene (CRHR1), the gene coding for the FK506 binding protein 5 (FKBP5) and the Glucocorticoid receptor gene (NR3c1) along with a haplotype formed by the SNPs in CRHR1. A significant association was found between recurrent maternal depression and depression symptoms in offspring. None of the SNPs were associated with offspring depression symptoms and associations did not differ according to the presence of recurrent maternal depression. However, caution is required due to a relatively small sample size.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Gene–environment interaction; Child and adolescent depression; Maternal depression; Single nucleotide polymorphism
Publisher: Springer Verlag
ISSN: 0001-8244
Last Modified: 06 Jun 2019 20:40
URI: http://orca.cf.ac.uk/id/eprint/23229

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