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Peroxynitrite-mediated lipid oxidation and nitration: mechanisms and consequences

Rubbo, Homero, Trostchansky, Andrés and O'Donnell, Valerie Bridget 2009. Peroxynitrite-mediated lipid oxidation and nitration: mechanisms and consequences. Archives of Biochemistry and Biophysics 484 (2) , pp. 167-172. 10.1016/j.abb.2008.11.007

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Abstract

Lipid oxidation and nitration represents a novel area of research of relevance in the understanding of inflammatory processes. Peroxynitrite, the product of the diffusion-limited reaction between nitric oxide and superoxide anion, mediates oxidative modifications in lipid systems including cell membranes and lipoproteins. In this review, we discuss the mechanisms of lipid oxidation and nitration by peroxynitrite as well as the influence of physiological molecules and cell targets to redirect peroxynitrite reactivity. We also provide evidence to support that oxidation/nitration of lipids results in the formation of novel signaling modulators of key lipid-metabolizing enzymes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: peroxynitrite, lipid oxidation, nitrated fatty acids, arachidonic acid, cyclooxygenase, lipoxygenase, nitric oxide
Publisher: Elsevier
ISSN: 0003-9861
Last Modified: 04 Jun 2017 03:37
URI: http://orca.cf.ac.uk/id/eprint/23632

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