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Loss of tight junction barrier function and its role in cancer metastasis

Martin, Tracey Amanda and Jiang, Wen Guo 2009. Loss of tight junction barrier function and its role in cancer metastasis. Biochimica et Biophysica Acta (BBA) - Biomembranes 1788 (4) , pp. 872-891. 10.1016/j.bbamem.2008.11.005

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As the most apical structure between epithelial and endothelial cells, tight junctions (TJ) are well known as functioning as a control for the paracellular diffusion of ions and certain molecules. It has however, become increasingly apparent that the TJ has a vital role in maintaining cell to cell integrity and that the loss of cohesion of the structure can lead to invasion and thus metastasis of cancer cells. This article will present data showing how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the successful metastasis of a number of different cancer types.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Tight junction; Barrier function; Cancer; Metastasis
Publisher: Elsevier
ISSN: 0005-2736
Last Modified: 05 Sep 2020 01:24

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