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Copy number variation in schizophrenia in the Japanese population

Ikeda, Masashi, Aleksic, Branko, Kirov, George, Kinoshita, Yoko, Yamanouchi, Yoshio, Kitajima, Tsuyoshi, Kawashima, Kunihiro, Okochi, Tomo, Kishi, Taro, Zaharieva, Irina Takova, Owen, Michael John, O'Donovan, Michael Conlon, Ozaki, Norio and Iwata, Nakao 2010. Copy number variation in schizophrenia in the Japanese population. Biological Psychiatry 67 (3) , pp. 283-286. 10.1016/j.biopsych.2009.08.034

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Abstract

Background: Copy number variants (CNVs) have been shown to increase the risk to develop schizophrenia. The best supported findings are at 1q21.1, 15q11.2, 15q13.3, and 22q11.2 and deletions at the gene neurexin 1 (NRXN1). Methods: In this study, we used Affymetrix 5.0 arrays to investigate the role of rare CNVs in 575 patients with schizophrenia and 564 control subjects from Japan. Results: There was a nonsignificant trend for excess of rare CNVs in schizophrenia (p � .087); however, we did not confirm the previously implicated association for very large CNVs (�500 kilobase [kb]) in this population. We provide support for three previous findings in schizophrenia, as we identified one deletion in a case at 1q21.1, one deletion within NRXN1, and four duplications in cases and one in a control subject at 16p13.1, a locus first implicated in autism and later in schizophrenia. Conclusions: In this population, we support some of the previous findings in schizophrenia but could not find an increased burden of very large (�500 kb) CNVs, which was proposed recently. However, we provide support for the role of CNVs at 16p13.1, 1q21.1, and NRXN1.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Deletion; duplication; NRXN1; 16p13.1; 1q21.1; schizophrenia
Publisher: Elsevier
ISSN: 0006-3223
Last Modified: 10 Oct 2017 14:05
URI: http://orca.cf.ac.uk/id/eprint/23828

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