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Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum

Kumar, Sanjay, Hall, Roger J. C., Mani, Ali R., Moore, Kevin P., Camici, Paolo G., Rimoldi, Ornella E., Williams, Alan John and Macleod, Kenneth T. 2009. Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum. Biochemical and Biophysical Research Communications 387 (1) , pp. 77-82. 10.1016/j.bbrc.2009.06.115

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Abstract

Myocardial stunning (temporary post-ischaemic contractile dysfunction) may be caused by oxidative stress and/or impaired myocyte calcium homeostasis. Regional myocardial stunning was induced in open-chest pigs (segment shortening reduced to 68.3+/-4.7% of baseline) by repetitive brief circumflex coronary occlusion (I/R). Reduced glutathione was depleted in stunned myocardium (1.34+/-0.06 vs. 1.77+/-0.11 nmol/mg, p=0.02 vs. remote myocardium) indicating regional oxidant stress, but no regional differences were observed in protein-bound 3-nitrotyrosine or S-nitrosothiol content. Repetitive I/R did not affect myocardial quantities of the sarcolemmal sodium-calcium exchanger, L-type channel, SR calcium ATPase and phospholamban, or the kinetics of ligand binding to L-type channels and SR calcium release channels. However, initial rates of oxalate-supported (45)Ca uptake by SR were impaired in stunned myocardium (41.3+/-13.5 vs. 73.0+/-15.6 nmol/min/mg protein, p=0.03). The ability of SR calcium ATPase to sequester cytosolic calcium is impaired in stunned myocardium. This is a potential mechanism underlying contractile dysfunction.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Myocardialstunning; Ischaemia; Reperfusion; Calcium; Sarcoplasmicreticulum; Reactive nitrogen species
Publisher: Elsevier
ISSN: 0006-291X
Last Modified: 12 Jun 2019 02:28
URI: http://orca.cf.ac.uk/id/eprint/23843

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