Endocrine oncology in pregnancy

Lansdown, Andrew John and Rees, Dafydd Aled ORCID: https://orcid.org/0000-0002-1165-9092 2011. Endocrine oncology in pregnancy. Best Practice & Research Clinical Endocrinology & Metabolism 25 (6) , pp. 911-926. 10.1016/j.beem.2011.06.011

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Abstract

Endocrine tumours occur rarely in pregnant women but present clinicians with unique challenges. A high index of suspicion is often required to make a diagnosis since the symptoms and signs associated with many of these tumours, including insulinoma, adrenocortical carcinoma and phaeochromocytoma, mimic those of normal pregnancy or its complications, such as pre-eclampsia. The evidence base which informs management is very limited hence decisions on investigation and therapy must be individualised and undertaken jointly by the multidisciplinary medical team and the patient. The optimal strategy will depend on the nature and stage of the endocrine tumour, gestational stage, treatments available and patient wishes. Thus, surgical intervention, appropriately timed, may be considered in pregnancy for resectable adrenocortical carcinoma or phaeochromocytoma, but delayed until the postpartum period for well-differentiated thyroid cancer. Medical therapy may be required to reduce the drive to tumour growth, control symptoms of hormone excess and to minimise the risks of surgery, anaesthesia or labour.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	pregnancy; thyroid cancer; adrenocortical carcinoma; Cushing’s syndrome; phaeochromocytoma; paraganglioma; neuroendocrine tumour; carcinoid; octreotide
Publisher:	Elsevier
ISSN:	1521-690X
Last Modified:	05 Nov 2022 15:43
URI:	https://orca.cardiff.ac.uk/id/eprint/23871

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