Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Tissue transglutaminase and factor XIII in cartilage and bone remodeling

Aeschlimann, Daniel, Mosher, D. and Paulsson, M. 1996. Tissue transglutaminase and factor XIII in cartilage and bone remodeling. Seminars in Thrombosis and Hemostasis 22 (5) , pp. 437-443. 10.1055/s-2007-999043

Full text not available from this repository.

Abstract

While it is well established that factor XIII functions in crosslinking of the fibrin clot during blood coagulation and in wound healing, the physiological role of tissue transglutaminase is still unclear. Recent studies suggest that the expression of tissue transglutaminase correlates with (terminal) differentiation of cells and that the enzyme may play a role in extracellular matrix remodeling. In cartilage, tissue transglutaminase expression is restricted to hypertrophic chondrocytes and the enzyme is externalized at a distinct step in the chondrocyte maturation program. Upon activation by Ca2+, the transglutaminase modifies matrix constituents in a way that might predispose the matrix for the subsequent mineralization. Crosslinks of the structure gamma-glutamyl-epsilon-lysine are also abundant in bone matrix, but the transglutaminase expressed by osteoblasts and presumably involved in crosslinking of newly formed osteoid is likely to be distinct from both tissue transglutaminase and factor XIII. Matrix proteins thought to be crosslinked by transglutaminases in cartilage and bone matrix include glycoproteins such as osteonectin, osteopontin, fibronectin, fibrillin, and collagens II, III, V, and XI. Expression of the A subunit of factor XIII is restricted to megakaryocytes in the bone marrow cavity, and factor XIIIa is abundant in platelets that probably provide the major source for factor XIII in plasma.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Factor XIII - tissue transglutaminase - bone - cartilage - extracellular matrix
Publisher: Georg Thieme Verlag
ISSN: 0094-6176
Last Modified: 04 Jun 2017 03:38
URI: http://orca.cf.ac.uk/id/eprint/23886

Citation Data

Cited 101 times in Google Scholar. View in Google Scholar

Cited 94 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item