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Transglutaminase activity in the eye: cross-linking in epithelia and connective tissue structures

Raghunath, M., Cankay, R., Kubitscheck, U., Fauteck, J. D., Mayne, R., Aeschlimann, Daniel and Schlötzer-Schrehardt, U. 1999. Transglutaminase activity in the eye: cross-linking in epithelia and connective tissue structures. Investigative Ophthalmology & Visual Science 40 (12) , pp. 2780-2787.

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Abstract

TGase 2 appears to be an important cross-linker and thus stabilizer of ocular connective tissue. In particular, the zonular fibers are a major target for TGase 2. This is of relevance in hereditary microfibrillopathies such as Marfan syndrome, which exhibits distinct ocular manifestations such as elongated bulbus, retinal detachment, and subluxation of the lens. Purified or recombinant TGase might be of therapeutic use in the future.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: Q Science > Q Science (General)
R Medicine > RE Ophthalmology
Additional Information: Confirmation received by publisher on 21 February 2014 that publisher's pdf can be self-archived 6 months after publication.
Publisher: Association for Research in Vision and Ophthalmology
ISSN: 0146-0404
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 03:38
URI: http://orca.cf.ac.uk/id/eprint/23899

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