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Effect of a liposomal spray on the pre-ocular tear film

Craig, Jennifer P., Purslow, Christine, Murphy, Paul James and Wolffsohn, James S.W. 2010. Effect of a liposomal spray on the pre-ocular tear film. Contact Lens and Anterior Eye 33 (2) , pp. 83-87. 10.1016/j.clae.2009.12.007

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Abstract

With the potential to address evaporative dry eye, a novel spray has been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid. This study evaluated the short-term effects of liposomal spray application on the lipid and stability characteristics of the pre-ocular tear film in normal eyes. Twenty-two subjects (12M, 10F) aged 35.1 ± 7.1 years participated in this prospective, randomised, double-masked investigation in which the liposomal spray was applied to one eye, and an equal volume of saline spray (control) applied to the contralateral eye. Lipid layer grade (LLG), non-invasive tear film stability (NIBUT) and tear meniscus height (TMH) were evaluated at baseline, and at 30, 60, 90 and 135 min post-application. Subjective reports of comfort were also compared. Treated and control eyes were not significantly different at baseline (p > 0.05). Post-application, LLG increased significantly, at 30 and 60 min, only in the treated eyes (p = 0.005). NIBUT also increased significantly in the treated eyes only (p < 0.001), at 30, 60 and 90 min. TMH did not alter significantly (p > 0.05). Comfort improved relative to baseline in 46% of treated and 18% of control eyes, at 30 min post-application. Of those expressing a preference in comfort between the eyes, 68% preferred the liposomal spray. Consistent with subjective reports of improved comfort, statistically and clinically significant improvements in lipid layer thickness and tear film stability are observed in normal eyes for ≥1 h after a single application of a phospholipid liposomal spray.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: Lipid layer; Tear film; Phospholipid; Liposomal spray; Stability
ISSN: 1367-0484
Last Modified: 04 Jun 2017 03:38
URI: https://orca.cardiff.ac.uk/id/eprint/23940

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