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Genome-Wide Association Study of Schizophrenia in a Japanese Population

Ikeda, Masashi, Aleksic, Branko, Kinoshita, Yoko, Okochi, Tomo, Kawashima, Kunihiro, Kushima, Itaru, Ito, Yoshihito, Nakamura, Yukako, Kishi, Taro, Okumura, Takenori, Fukuo, Yasuhisa, Williams, Hywel John, Hamshere, Marian Lindsay, Ivanov, Dobril, Inada, Toshiya, Suzuki, Michio, Hashimoto, Ryota, Ujike, Hiroshi, Takeda, Masatoshi, Craddock, Nicholas John, Kaibuchi, Kozo, Owen, Michael John, Ozaki, Norio, O'Donovan, Michael Conlon and Iwata, Nakao 2011. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biological Psychiatry 69 (5) , pp. 472-478. 10.1016/j.biopsych.2010.07.010

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Abstract

BACKGROUND: Genome-wide association studies have detected a small number of weak but strongly supported schizophrenia risk alleles. Moreover, a substantial polygenic component to the disorder consisting of a large number of such alleles has been reported by the International Schizophrenia Consortium. METHOD: We report a Japanese genome-wide association study of schizophrenia comprising 575 cases and 564 controls. We attempted to replicate 97 markers, representing a nonredundant panel of markers derived mainly from the top 150 findings, in up to three data sets totaling 1990 cases and 5389 controls. We then attempted to replicate the observation of a polygenic component to the disorder in the Japanese and to determine whether this overlaps that seen in UK populations. RESULTS: Single-locus analysis did not reveal genome-wide support for any locus in the genome-wide association study sample (best p = 6.2 × 10(-6)) or in the complete data set in which the best supported locus was SULT6B1 (rs11895771: p = 3.7 × 10(-5) in the meta-analysis). Of loci previously supported by genome-wide association studies, we obtained in the Japanese support for NOTCH4 (rs2071287: p(meta) = 5.1 × 10(-5)). Using the approach reported by the International Schizophrenia Consortium, we replicated the observation of a polygenic component to schizophrenia within the Japanese population (p = .005). Our trans Japan-UK analysis of schizophrenia also revealed a significant correlation (best p = 7.0 × 10(-5)) in the polygenic component across populations. CONCLUSIONS: These results indicate a shared polygenic risk of schizophrenia between Japanese and Caucasian samples, although we did not detect unequivocal evidence for a novel susceptibility gene for schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Genome-wideassociationstudy; NOTCH4; polygenic component; schizophrenia; SULT6B1
Publisher: Elsevier
ISSN: 0006-3223
Date of Acceptance: 9 July 2010
Last Modified: 14 Mar 2018 15:25
URI: http://orca.cf.ac.uk/id/eprint/23988

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