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Cell biology of thiazide bone effects

Gamba, Gerardo and Riccardi, Daniela 2008. Cell biology of thiazide bone effects. Presented at: 2nd International Urolithiasis Research Symposium, Indianapolis, IN, USA, 17-18 April 2008. Published in: Evan, A. P., Williams, J. C., Lingeman, J. E. and McAteer, J. A. eds. Renal Stone Disease 2: 2nd International Urolithiasis Research Symposium, Indianapolis, Indiana, 17-18 April 2008. AIP Conference Proceedings , vol. 1049. New York: American Institute of Physics, pp. 44-52. 10.1063/1.2998060

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Abstract

The thiazide‐sensitive Na+:Cl− cotransporter (NCC) is the major pathway for salt reabsorption in the mammalian kidney. The activity of NCC is not only related to salt metabolism, but also to calcium and magnesium homeostasis due to the inverse relationship between NCC activity and calcium reabsorption. Hence, the thiazide‐type diuretics that specifically block NCC have been used for years, not only for treatment of hypertension and edematous disease, but also for the management of renal stone disease. Epidemiological studies have shown that chronic thiazide treatment is associated with higher bone mineral density and reduced risk of bone fractures, which can only partly be explained in terms of their effects on the kidney. In this regard, we have recently shown that NCC is expressed in bone cells and that inhibition of NCC in bone, either by thiazides or by reduction of NCC protein with specific siRNA, is associated with increased mineralization in vitro. These observations open a field of study to begin to understand the cell biology of the beneficial effects of thiazides in bone.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: diseases; crystallisation; minerals
Publisher: American Institute of Physics
ISBN: 9780735405776
Last Modified: 04 Jun 2017 03:38
URI: http://orca.cf.ac.uk/id/eprint/24053

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