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To B or not to B - pathogenic and regulatory B cells in autoimmune diabetes

Wong, Florence Susan, Hu, Changyun, Xiang, Yufei and Wen, Li 2010. To B or not to B - pathogenic and regulatory B cells in autoimmune diabetes. Current Opinion in Immunology 22 (6) , pp. 723-731. 10.1016/j.coi.2010.10.002

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Abstract

B cells have a vitally important function to produce antibodies which are directly pathogenic in some autoimmune diseases. However, it is clear that a number of other B cell functions are also critical in the pathogenesis of organ-specific autoimmune diseases that were previously thought to be mainly T cell mediated. Therapeutic agents that target B cells and their functions may therefore be of considerable importance in these autoimmune diseases. In this review, we will focus on B cell characteristics and functions that contribute to type 1 diabetes (T1D) and discuss why anti-B cell treatment may be effective in T1D, a disease that was previously considered to be primarily T cell mediated.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RB Pathology
Publisher: Elsevier
ISSN: 0952-7915
Last Modified: 04 Jun 2017 03:39
URI: http://orca.cf.ac.uk/id/eprint/24410

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