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Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology

Blain, Emma Jane 2009. Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology. International Journal of Experimental Pathology 90 (1) , pp. 1-15. 10.1111/j.1365-2613.2008.00625.x

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Abstract

The cytoskeleton of all cells is a three-dimensional network comprising actin microfilaments, tubulin microtubules and intermediate filaments. Studies in many cell types have indicated roles for these cytoskeletal proteins in many diverse cellular processes including alteration of cell shape, movement of organelles, migration, endocytosis, secretion, cell division and extracellular matrix assembly. The cytoskeletal networks are highly organized in structure enabling them to fulfil their biological functions. This review will primarily focus on the organization and function of the three major cytoskeletal networks in articular cartilage chondrocytes. Articular cartilage is a major load-bearing tissue of the synovial joint; it is well known that the cytoskeleton acts as a physical interface between the chondrocytes and the extracellular matrix in ‘sensing’ mechanical stimuli. The effect of mechanical load on cytoskeletal element expression and organization will also be reviewed. Abnormal mechanical load is widely believed to be a risk factor for the development of osteoarthritis. Several studies have intimated that the major cytoskeletal networks are disorganized or often absent in osteoarthritic cartilage chondrocytes. The implications and possible reasoning for this are more widely discussed and placed into context with their potential relevance to disease and therapeutic strategies. Keywords: actin microfilaments, articular cartilage, chondrocyte, cytoskeleton, tubulin microtubules, vimentin intermediate filaments.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RB Pathology
Uncontrolled Keywords: actin microfilaments; articular cartilage; chondrocyte, cytoskeleton; tubulin microtubules; vimentin intermediate filaments
Publisher: Blackwell Publishing
ISSN: 0959-9673
Last Modified: 29 Apr 2019 09:54
URI: http://orca.cf.ac.uk/id/eprint/24562

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