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Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene

Lancaster, Thomas M., Baird, Alison, Wolf, Claudia, Jackson, Margaret C., Johnston, Stephen J., Donev, Rossen, Thome, Johannes and Linden, David Edmund Johannes 2011. Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene. European Neuropsychopharmacology 21 (12) , pp. 880-884. 10.1016/j.euroneuro.2011.02.001

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Recent GWAS identified a risk variant for Alzheimer's disease (AD) at a locus (rs11136000) of the clusterin gene (CLU). Here we use functional magnetic resonance imaging (fMRI) during working memory to probe the effect of the risk variant on brain activation in healthy individuals. Participants with the CLU risk genotype had higher activity than participants with the protective allele in frontal and posterior cingulate cortex and the hippocampus, particularly during high memory demand. These results inform pathophysiological models of the preclinical progression of AD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
Uncontrolled Keywords: Dementia; Genetic imaging; Working memory; Clusterin; Hippocampus; Prefrontal cortex
Publisher: Elsevier
ISSN: 0924-977X
Last Modified: 04 Jun 2017 03:41

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