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The nasal decongestant effect of xylometazoline in the common cold

Eccles, Ronald, Eriksson, Margareta, Garreffa, Steve and Chen, Shirley 2008. The nasal decongestant effect of xylometazoline in the common cold. American Journal of Rhinology 22 (5) , pp. 491-496. 10.2500/ajr.2008.22.3202

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Abstract

Background: Xylometazoline is a nasal decongestant spray that constricts nasal blood vessels and increases nasal airflow, enabling patients with a blocked nose to breathe more easily. The purpose of this study was to characterize objectively and subjectively the decongestant and additional effects of xylometazoline in the common cold. Methods: A double-blind, placebo-controlled, parallel group study was performed. Patients with a common cold (n = 61) were treated with xylometazoline 0.1% (n = 29) or placebo (saline solution; n = 32; 1 spray three times a day for up to 10 days). The primary objective was to determine the decongestant effect (nasal conductance); the secondary objectives were to determine the peak subjective effect (visual analog scale), duration of relief of nasal congestion, total and individual cold symptoms and general well-being (patients' daily diary), and adverse events (AEs). Results: The decongestant effect of xylometazoline was significantly greater than placebo, as shown by the nasal conductance at 1 hour (384.23 versus 226.42 cm3/s; p ≤ 0.0001) and peak subjective effect (VAS, 20.7 mm versus 31.5 mm; p = 0.0298). Nasal conductance was significantly superior for up to 10 hours (p = 0.0009) and there was a trend in favor of xylometazoline for up to 12 hours (not statistically significant). Xylometazoline significantly improved total and some individual common cold symptoms scores (p < 0.05), leading to significantly greater patient general evaluation and satisfaction with treatment (p < 0.05). Nineteen AEs were reported: 8 with xylometazoline (all mild-moderate) and 11 with placebo (1 severe). Conclusion: Xylometazoline is an effective and well-tolerated decongestant nasal spray that significantly relieved nasal congestion compared with placebo in the common cold and provided long-lasting relief with just 1 spray, helping patients to breathe more easily for a longer period of time.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
R Medicine > RF Otorhinolaryngology
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: common cold; decongestant; nasal congestion; Otrivin; placebo effect; rhinomanometry; topical nasal decongestant; xylometazoline
Publisher: OceanSide Publications
ISSN: 1050-6586
Last Modified: 04 Jun 2017 03:41
URI: http://orca.cf.ac.uk/id/eprint/24891

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