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Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Robinson, Matthew J., Osorio, Fabiola, Rosas, Marcela, Freitas, Rui P., Schweighoffer, Edina, Gross, Olaf, Verbeek, J. Spief, Ruland, Jurgen, Tybulewicz, Victor, Brown, Gordon D., Moita, Luis Fereirra, Taylor, Philip Russel and Reis e Sousa, Caetano 2009. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. Journal of Experimental Medicine 206 (9) , pp. 2037-2051. 10.1084/jem.20082818

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Abstract

Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi, have defined a novel innate signaling pathway involving Syk kinase and the adaptor CARD9, which is critical for inducing Th17 responses to fungal infection. We show that another C-type lectin, Dectin-2, also signals via Syk and CARD9, and contributes to dendritic cell (DC) activation by fungal particles. Unlike Dectin-1, Dectin-2 couples to Syk indirectly, through association with the FcRγ chain. In a model of Candida albicans infection, blockade of Dectin-2 did not affect innate immune resistance but abrogated Candida-specific T cell production of IL-17 and, in combination with the absence of Dectin-1, decreased Th1 responses to the organism. Thus, Dectin-2 constitutes a major fungal PRR that can couple to the Syk–CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0022-1007/ (accessed 12/03/2014).
Publisher: Rockerfeller University Press
ISSN: 0022-1007
Date of First Compliant Deposit: 30 March 2016
Last Modified: 03 Mar 2020 02:52
URI: http://orca.cf.ac.uk/id/eprint/24979

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