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Male infertility-linked point mutation disrupts the Ca2+oscillation-inducing and PIP2hydrolysis activity of sperm PLCζ

Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian Lewis, Cumbes, Bevan, Nounesis, George, Swann, Karl and Lai, Francis Anthony 2011. Male infertility-linked point mutation disrupts the Ca2+oscillation-inducing and PIP2hydrolysis activity of sperm PLCζ. Biochemical Journal 434 (2) , pp. 211-217. 10.1042/BJ20101772

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Abstract

A male infertility-linked human PLCζ (phospholipase Cζ) mutation introduced into mouse PLCζ completely abolishes both in vitro PIP2 (phosphatidylinositol 4,5-bisphosphate) hydrolysis activity and the ability to trigger in vivo Ca2+ oscillations in mouse eggs. Wild-type PLCζ initiated a normal pattern of Ca2+ oscillations in eggs in the presence of 10-fold higher mutant PLCζ, suggesting that infertility is not mediated by a dominant-negative mechanism.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: calcium oscillation; egg activation; fertilization; infertility; phospholipase C (PLC); phospholipase Cζ (PLCζ)
Publisher: Biochemical Society
ISSN: 0264-6021
Related URLs:
Last Modified: 07 May 2019 19:18
URI: http://orca.cf.ac.uk/id/eprint/25138

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