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HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells

Campo, M. S., Graham, S. V., Cortese, M. S., Ashrafi, G. H., Araibi, E. H., Dornan, E. S., Miners, Kelly Louise, Nunes, Claudia Trindade and Man, Stephen Tze Kwung 2010. HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells. Virology 407 (1) , pp. 137-142. 10.1016/j.virol.2010.07.044

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Abstract

HPV-16 is the major causes of cervical cancer. Persistence of infection is a necessary event for progression of the infection to cancer. Among other factors, virus persistence is due the viral proteins fighting the immune response. HPV-16 E5 down-regulates MHC/HLA class I, which is much reduced on the cell surface and accumulates in the Golgi apparatus in cells expressing E5. This effect is observed also in W12 cells, which mimic early cervical intraepithelial progression to cervical cancer. The functional effect of MHC I down-regulation on human CD8 T cells is not known, because of the need for HLA-matched, HPV-specific T cells that recognise E5 expressing-cells. Here we employ a heterologous cell/MHC I system which uses mouse cells expressing both E5 and HLA-A2, and A2-restricted CTLs; we show that the E5-induced reduction of HLA-A2 has a functional impact by reducing recognition of E5 expressing cells by HPV specific CD8+ T cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR355 Virology
R Medicine > R Medicine (General)
Uncontrolled Keywords: HPV-16 E5; W12; HLA down-regulation; CD8 T cells; Immuno evasion
Publisher: Elsevier
ISSN: 0042-6822
Last Modified: 04 Jun 2017 03:44
URI: http://orca.cf.ac.uk/id/eprint/25661

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