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Human papillomavirus genotype testing combined with cytology as a 'test of cure' post treatment: the importance of a persistent viral infection

Jones, Joanne, Saleem, Azka, Rai, Nima, Shylasree, T. S., Ashman, Suzanne, Gregory, Kate, Powell, Ned George, Tristram, Amanda Jane, Fiander, Alison Nina and Hibbitts, Samantha Jayne 2011. Human papillomavirus genotype testing combined with cytology as a 'test of cure' post treatment: the importance of a persistent viral infection. Journal of Clinical Virology 52 (2) , pp. 88-92. 10.1016/j.jcv.2011.06.021

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Abstract

Background Human Papillomavirus (HPV) testing has been evaluated as a test of cure in patients following treatment of high-grade cervical intraepithelial neoplasia (CIN2+). Studies show that women who are HPV and cytology negative post treatment can be safely returned to routine recall. The management strategy for HPV positive women requires confirmation. Objective To evaluate the clinical utility of the PapilloCheck® genotyping assay for predicting disease recurrence in a test of cure setting. Study design Ninety-eight women (19–52 years) treated for CIN2+ by large loop excision of the transformation zone (LLETZ) were evaluated with samples taken before and 6 months after treatment for HPV testing. Cytology and histology were available from recruitment until 24 months post treatment. Results Recurrent disease was evident in 4% of patients with 2 cases low-grade and 2 cases of high-grade disease. In women with no disease recurrence, 40% (95% CI 30.42–51.05%) were high risk (HR) HPV negative post LLETZ. Both cases with high-grade disease had persistent HPV16 infection. Genotyping before and after treatment revealed 83% (95% CI 75.74–88.78%) of total viral infections were cleared and 17% (95% CI 11.22–24.26) viral infections persisted. Post treatment, combined cytology and HPV test results predicted CIN2+ with 100% sensitivity, 91.7% specificity, 100% NPV and 20% PPV and measuring viral persistence marginally increased specificity and PPV. Conclusion Post treatment, cytology combined with a single HR HPV test has high sensitivity and specificity for predicting disease recurrence. HPV genotyping before and after LLETZ identifies persistent viral infections and could help refine patient management.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords: cervical screening, HPV genotyping, test of cure, PapilloCheck®
Publisher: Elsevier
ISSN: 1386-6532
Last Modified: 08 Jul 2019 00:05
URI: http://orca.cf.ac.uk/id/eprint/25998

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