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Standards of care for patients with invasive fungal infections within the United Kingdom: a national audit

Schelenz, S., Barnes, Rosemary Ann, Kibbler, C. C., Jones, B. L. and Denning, D. W. 2009. Standards of care for patients with invasive fungal infections within the United Kingdom: a national audit. Journal of Infection 58 (2) , pp. 145-153. 10.1016/j.jinf.2008.12.006

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Objective The objective of this study was to audit the compliance and implementation of the British Society for Medical Mycology standards of care for patients with invasive infections in UK hospitals. Methods A multidisciplinary audit questionnaire regarding the processing of microbiology and histopathology specimens, radiology imaging and clinical management of patients with invasive fungal infections was distributed to UK hospitals. Results The study has shown that speciation of Candida and Aspergillus isolates from sterile sites was performed in 42–98% of hospitals. Microscopy of bronchoscopy specimens was not undertaken in 13 of 62 (21%) laboratories. Cryptococcal culture and antigen were undertaken routinely in abnormal CSF in 40–75% and 31–83% of at-risk patients but only in 12% of abnormal CSFs in patients without risk factors. Detailed fungal morphology was provided by <50% of histopathology departments. Most hospitals provided a timely HRCT or MRI on patients suspected to have an invasive fungal infection, but early treatment failed to occur in 15% of hospitals. In patients presenting with candidaemia, central venous catheters (CVC) were not changed routinely within 48 h in 15%. Conclusion Improvement in microbiology and histopathology specimen processing as well as rapid interventions such as initiation of anti-fungal therapy or CVC line removal could improve diagnostic rates and clinical outcomes of invasive fungal infections.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology
Uncontrolled Keywords: invasive fungal infections, standards, audit
Publisher: Elsevier
ISSN: 0163-4453
Last Modified: 04 Jun 2017 03:45

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