Design of photocontrolled RNA-binding peptidomimetics

Mart, Robert J., Wysoczanski, Piotr, Kneissl, Sabine, Ricci, Antonio, Brancale, Andrea and Allemann, Rudolf Konrad 2012. Design of photocontrolled RNA-binding peptidomimetics. ChemBioChem 13 (4) , pp. 515-519. 10.1002/cbic.201100800

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Abstract

The first examples of photocontrolled RNA binding peptides are described. The large number of positively charged sides chains in the Rev response element (RRE) of an HIV type I targeting α-helix imposes constraints on the choice of azobenzene-derived crosslinker.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Pharmacy Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	azo compounds; peptides; photochromism; protein modifications; RNA recognition
Publisher:	Wiley
ISSN:	1439-4227
Funders:	EPSRC
Last Modified:	08 Jan 2018 21:33
URI:	http://orca.cf.ac.uk/id/eprint/26040

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