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The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype

Walsh, John P., Berry, Jemma, Liu, Shu, Panicker, Vijay, Dayan, Colin Mark, Brix, Thomas H., Hegedüs, Laszlo, Hou, Peng, Shi, Bingyin and Morahan, Grant 2011. The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype. Clinical Endocrinology 74 (4) , pp. 508-512. 10.1111/j.1365-2265.2010.03970.x

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Abstract

Background Common variants in the interleukin 12B (IL12B) gene are associated with predominantly inflammatory (Th1) or antibody-mediated (Th2) immune responses. As Hashimoto’s disease and Graves’ disease are thought to arise from mainly Th1 and Th2 immune responses respectively, we hypothesized that IL12B genotype may influence the clinical presentation of autoimmune thyroid disease. Objective We tested for differences in IL12B genotype between Graves’ disease and Hashimoto’s disease. Patients We studied a discovery cohort of 203 Australian women and 37 men with autoimmune thyroid disease, a replication cohort of 100 European men and a cohort of 146 Chinese men. Intervention We analysed three IL12B variants: rs41292470, in the promoter; rs3212227, in the 3¢ untranslated region and rs6887695, located 60 kilobases upstream from the coding region. Results In the discovery cohort, rs41292470 and rs3212227 genotypes did not differ significantly between Hashimoto’s disease and Graves’ disease. In Australian men (but not women), rs6887695 genotype differed between Hashimoto’s disease and Graves’ disease, with a minor allele frequency (MAF) of 14% and 41%, respectively (P = 0Æ034). This result was confirmed in the European men (MAF 24% and 41%; P = 0Æ013). On combined analysis of Australian, European and Chinese men (N = 285), the difference was highly significant (MAF 23% and 45%; P = 3 · 10)5). In 233 men without thyroid disease, the MAF was 34%, significantly different from Graves’ disease (P = 0Æ005) and Hashimoto’s disease (P = 0Æ029). Conclusion In men with autoimmune thyroid disease, a common variant located upstream of the IL12B coding region may influence wheth

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
Publisher: Blackwell Publishing
ISSN: 0300-0664
Last Modified: 04 Jun 2017 03:46
URI: http://orca.cf.ac.uk/id/eprint/26375

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