Microstructural maturation of the human brain from childhood to adulthood

Lebel, C., Walker, L., Leemans, Alexander, Phillips, L. and Beaulieu, C. 2008. Microstructural maturation of the human brain from childhood to adulthood. NeuroImage 40 (3) , pp. 1044-1055. 10.1016/j.neuroimage.2007.12.053

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Abstract

Brain maturation is a complex process that continues well beyond infancy, and adolescence is thought to be a key period of brain rewiring. To assess structural brain maturation from childhood to adulthood, we charted brain development in subjects aged 5 to 30 years using diffusion tensor magnetic resonance imaging, a novel brain imaging technique that is sensitive to axonal packing and myelination and is particularly adept at virtually extracting white matter connections. Age-related changes were seen in major white matter tracts, deep gray matter, and subcortical white matter, in our large (n = 202), age-distributed sample. These diffusion changes followed an exponential pattern of maturation with considerable regional variation. Differences observed in developmental timing suggest a pattern of maturation in which areas with fronto-temporal connections develop more slowly than other regions. These in vivo results expand upon previous postmortem and imaging studies and provide quantitative measures indicative of the progression and magnitude of regional human brain maturation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	1053-8119
Last Modified:	12 Jun 2019 02:27
URI:	https://orca.cardiff.ac.uk/id/eprint/26656

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