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On the construction of an inter-subject diffusion tensor magnetic resonance atlas of the healthy human brain

Van Hecke, Wim, Sijbers, Jan, D'Agostino, Emiliano, Maes, Frederik, De Backer, Steve, Vandervliet, Evert, Parizel, Paul M. and Leemans, Alexander 2008. On the construction of an inter-subject diffusion tensor magnetic resonance atlas of the healthy human brain. NeuroImage 43 (1) , pp. 69-80. 10.1016/j.neuroimage.2008.07.006

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Abstract

Voxel based morphometry (VBM) has been increasingly applied to detect diffusion tensor (DT) image abnormalities in patients for different pathologies. An important requisite for a robust VBM analysis is the availability of a high-dimensional non-rigid coregistration technique that is able to align both the spatial and the orientational DT information. Consequently, there is a need for an inter-subject DTI atlas as a group specific reference frame that also contains this orientational DT information. In this work, a population based DTI atlas has been developed that incorporates such orientational DT information with high accuracy and precision. The proposed methodology for constructing such an atlas is compared with a subject based DTI atlas, in which a single subject is selected as the reference image. Our results demonstrate that the population based atlas framework is more accurate with respect to the underlying diffusion information.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Psychology
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Diffusion tensor imaging; Non-rigid coregistration; Inter-subject group atlas; Diffusion tensor tractography
Publisher: Elsevier
ISSN: 1053-8119
Last Modified: 12 Jun 2019 02:28
URI: https://orca.cardiff.ac.uk/id/eprint/26668

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