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Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm

Kontis, Dimitris, Catani, Marco, Cuddy, Marion, Walshe, Muriel, Nosarti, Chiara, Jones, Derek K., Wyatt, John, Rifkin, Larry, Murray, Robin and Allin, Matthew 2009. Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm. NeuroReport 20 (4) , pp. 424-428. 10.1097/WNR.0b013e328325a8f9

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Very preterm birth (before 33 weeks gestation) is associated with the white matter damage, and a common sequel is reduced size and altered shape of the corpus callosum. We used diffusion tensor MRI to assess the corpus callosum in 63 very preterm and 45 term-born young adults. Indices of white matter microstructure [fractional anisotropy (FA) and mean diffusivity (MD)] were obtained for the genu, body and splenium. Very preterm females had higher MD in the genu than term-born females, indicating altered white matter microstructure. This was associated with lower performance IQ. The groups demonstrated different patterns of correlations between verbal learning and tract-specific FA and MD, consistent with the reorganization of white matter structure in adults born very preterm.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RG Gynecology and obstetrics
Publisher: Lippincott, Williams & Wilkins
ISSN: 0959-4965
Last Modified: 04 Jun 2017 03:47

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