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Lung function in mid-life compared with later life is a stronger predictor of arterial stiffness in men: The Caerphilly Prospective Study

Bolton, Charlotte Emma, Cockcroft, John Ronald, Sabit, Ramsey, Munnery, Margaret, McEniery, Carmel M, Wilkinson, Ian B, Ebrahim, Shah, Gallacher, John Edward, Shale, Dennis and Ben-Shlomo, Yoav 2009. Lung function in mid-life compared with later life is a stronger predictor of arterial stiffness in men: The Caerphilly Prospective Study. International Journal of Epidemiology 38 (3) , pp. 867-876. 10.1093/ije/dyn374

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Background: Increased arterial stiffness predicts future cardiovascular disease and in some cross-sectional studies it is related to worse lung function and obstructive pulmonary disease. We assessed the predictive value of lung function measured in mid-life as compared with later life on arterial stiffness in the Caerphilly Prospective Study (CaPS). Methods: Men aged 47–67 years had lung function measured between 1984 and 1988 and repeated between 2002 and 2004 (n = 827) as well as having carotid-femoral pulse wave velocity (PWV) measured. Results: Both forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in mid-life and later life were inversely associated with PWV (P < 0.0001) but mid-life measures were stronger predictors. Only mid-life measures remained predictors after mutual adjustment (FEV1 mid-life β coeff. −0.65, 95% CI −1.04, −0.26, P < 0.0001; FVC mid-life β coeff. −0.52, 95% CI −0.82, −0.23, P < 0.0001). Adjustment for smoking status, early life, inflammatory and metabolic factors in sub-groups did not markedly change the associations. Conclusions: Mid-life lung function is a stronger risk factor than in later life for arterial stiffness in men. It is possible that developmental factors influence both lung function and arterial stiffness. Lung function assessment in mid-life may identify individuals at greater risk of their future cardiovascular disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine
Uncontrolled Keywords: Epidemiology, cardiovascular disease, lung function, arterial stiffness
Publisher: Oxford University Press
ISSN: 0300-5771
Last Modified: 07 Aug 2020 14:21

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