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Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia

Wise, Richard Geoffrey, Pattinson, Kyle T.S., Bulte, Daniel P., Rogers, Richard, Tracey, Irene, Matthews, Paul M. and Jezzard, Peter 2010. Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia. Magnetic Resonance Imaging 28 (8) , pp. 1129-1134. 10.1016/j.mri.2010.06.002

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Relative cerebral blood volume (CBV) was estimated using a mild hypoxic challenge in humans, combined with BOLD contrast gradient-echo imaging at 3 T. Subjects breathed 16% inspired oxygen, eliciting mild arterial desaturation. The fractional BOLD signal change induced by mild hypoxia is expected to be proportional to CBV under conditions in which there are negligible changes in cerebral perfusion. By comparing the regional BOLD signal changes arising with the transition between normoxia and mild hypoxia, we calculated CBV ratios of 1.5±0.2 (mean±S.D.) for cortical gray matter to white matter and 1.0±0.3 for cortical gray matter to deep gray matter.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: BOLD; Hypoxia; Cerebral blood volume; fMRI
Additional Information: Proceedings of the International School on Magnetic Resonance and Brain Function
Publisher: Elsevier
ISSN: 0730-725X
Last Modified: 04 Jun 2017 03:47

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