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The prevalence of neuromyelitis optica in South East Wales

Cossburn, Mark, Tackley, George, Baker, K., Ingram, Gillian, Burtonwood, Mark, Malik, Gauhar, Pickersgill, Trevor, te Water Naude, Johann and Robertson, Neil 2012. The prevalence of neuromyelitis optica in South East Wales. European Journal of Neurology 19 (4) , pp. 655-659. 10.1111/j.1468-1331.2011.03529.x

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Abstract

Background and purpose: Neuromyeltis optica (NMO) is a neuroinflammatory disorder considered rare in Caucasian populations. However, accurate population-based epidemiological data for NMO and NMO spectrum disorder (NMO-SD) from Western populations employing validated diagnostic criteria remain limited. We sought therefore to estimate the prevalence and clinical features of NMO in a north European Caucasian population in South East Wales. Methods: Patients were identified by a comprehensive, multistage ascertainment strategy employing a regional neuroinflammatory disease register, hospital diagnostic databases personal physician referrals and regional requests for anti-aquaporin-4 antibodies (anti-AQP4). Results: Fourteen Caucasian patients (11 patients with NMO and three with NMO-SD) were identified in a population of 712 572 (19.6/million; 95% CIs: 12.2–29.7). There was an excess of females (female:male 12:2), 11/14 were anti-AQP4 positive and 5/14 had disease onset under the age of 20 years. Conclusion: This study suggests that NMO and related spectrum disorders are at least as frequent in Northern European populations as in non-Caucasian populations and that the demographic profile of prevalent patients differs from clinic-based cohorts.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: adult, myelitis, neuromyelitis optica, optic neuritis, paediatric, epidemiology
Publisher: Wiley
ISSN: 1351-5101
Last Modified: 08 Dec 2019 01:09
URI: http://orca.cf.ac.uk/id/eprint/27118

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