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Association of blaDHA-1 and qnrB genes carried by broad-host-range plasmids among isolates of Enterobacteriaceae at a Spanish hospital

Mata, C., Miró, E., Toleman, Mark Alexander Howard, Rivera, M. A., Walsh, Timothy Rutland and Navarro, F. 2011. Association of blaDHA-1 and qnrB genes carried by broad-host-range plasmids among isolates of Enterobacteriaceae at a Spanish hospital. Clinical Microbiology and Infection 17 (10) , pp. 1514-1517. 10.1111/j.1469-0691.2011.03539.x

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Abstract

A collection of 30 DHA-1-Enterobacteriaceae producers was examined for the presence of qnr genes. PCR-based replicon typing, plasmid profile and Southern hybridisation analyses revealed that all isolates co-harboured blaDHA-1 and qnrB genes on the same plasmid. All but one of these plasmids belonged to the L/M group. Genetic organization analyses of a randomly selected isolate revealed the co-localization of both genes on an IS26-composite transposon. As plasmids carrying both genes seem to have a high prevalence and a worldwide distribution, care should be taken when quinolones are used to treat infections caused by DHA-1 producers.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology
Uncontrolled Keywords: IncN, IS26-composite transposon, L/M incompatibility group, plasmid-mediated AmpC β-lactamases, plasmid-mediated quinolone resistance
Publisher: Wiley
ISSN: 1198-743X
Last Modified: 04 Jun 2017 03:48
URI: http://orca.cf.ac.uk/id/eprint/27177

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