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Dysbindin-1 genotype effects on emotional working memory

Wolf, C., Jackson, M. C., Kissling, C., Thome, J. and Linden, David Edmund Johannes 2011. Dysbindin-1 genotype effects on emotional working memory. Molecular Psychiatry 16 (2) , pp. 145-155. 10.1038/mp.2009.129

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We combined functional imaging and genetics to investigate the behavioral and neural effects of a dysbindin-1 (DTNBP1) genotype associated with the expression level of this important synaptic protein, which has been implicated in schizophrenia. On a working memory (WM) task for emotional faces, participants with the genotype related to increased expression showed higher WM capacity for happy faces compared to the genotype related to lower expression. Activity in several task-related brain areas with known DTNBP1 expression was increased, including hippocampus, temporal and frontal cortex. Although these increases occurred across emotions, they were mostly observed in areas whose activity correlated with performance for happy faces. This suggests effects of variability in DTNBP1 on emotion-specific WM capacity and region-specific task-related brain activation in humans. Synaptic effects of DTNBP1 implicate that altered dopaminergic and/or glutamatergic neurotransmission may be related to the increased WM capacity. The combination of imaging and genetics thus allows us to bridge the gap between the cellular/molecular and systems/behavioral level and extend the cognitive neuroscience approach to a comprehensive biology of cognition.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: dysbindin, genetic imaging, working memory, emotional faces, schizophrenia
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 04 Jun 2017 03:51

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