Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Transcerebral exchange kinetics of nitrite and calcitonin gene-related peptide in acute mountain sickness: evidence against trigeminovascular activation? [Letter]

Bailey, D. M., Taudorf, S., Berg, R. M. G., Jensen, L. T., Lundby, C., Evans, K. A., James, Philip Eurig, Pedersen, B. K. and Moller, K. 2009. Transcerebral exchange kinetics of nitrite and calcitonin gene-related peptide in acute mountain sickness: evidence against trigeminovascular activation? [Letter]. Stroke 40 (6) , pp. 2205-2208. 10.1161/STROKEAHA.108.543959

[thumbnail of Bailey 2009.pdf]
Preview
PDF - Published Version
Download (349kB) | Preview

Abstract

Background and Purpose— High-altitude headache is the primary symptom associated with acute mountain sickness, which may be caused by nitric oxide-mediated activation of the trigeminovascular system. Therefore, the present study examined the effects of inspiratory hypoxia on the transcerebral exchange kinetics of the vasoactive molecules, nitrite (NO2•), and calcitonin gene-related peptide (CGRP). Methods— Ten males were examined in normoxia and after 9-hour exposure to hypoxia (12.9% O2). Global cerebral blood flow was measured by the Kety-Schmidt technique with paired samples obtained from the radial artery and jugular venous bulb. Plasma CGRP and NO2• were analyzed via radioimmunoassay and ozone-based chemiluminescence. Net cerebral exchange was calculated by the Fick principle and acute mountain sickness/headache scores assessed via clinically validated questionnaires. Results— Hypoxia increased cerebral blood flow with a corresponding increase in acute mountain sickness and headache scores (P<0.05 vs normoxia). Hypoxia blunted the cerebral uptake of NO2•, whereas CGRP exchange remained unaltered. No relationships were observed between the change (hypoxia–normoxia) in cerebral NO2• or CGRP exchange and acute mountain sickness/headache scores (P>0.05).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: acute mountain sickness; brain; calcitonin gene-related peptide; nitrite
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0039-2499/ (accessed 19/02/2014).
Publisher: American Heart Association
ISSN: 0039-2499
Date of First Compliant Deposit: 30 March 2016
Last Modified: 08 May 2023 19:37
URI: https://orca.cardiff.ac.uk/id/eprint/28027

Citation Data

Cited 27 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics