Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Placenta growth Factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability [RETRACTED]

Cai, Jun, Wu, Lin, Qi, Xiaoping, Shaw, Lynn, Li Calzi, Sergio, Caballero, Sergio, Jiang, Wen Guo, Vinores, Stanley A., Antonetti, David, Ahmed, Asif, Grant, Maria B. and Boulton, Michael Edwin 2011. Placenta growth Factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability [RETRACTED]. PLoS ONE 6 (3) , e18076. 10.1371/journal.pone.0018076

PDF - Published Version
Available under License Creative Commons Attribution.

Download (4MB) | Preview


Increased vascular permeability is an early event characteristic of tissue ischemia and angiogenesis. Although VEGF family members are potent promoters of endothelial permeability the role of placental growth factor (PlGF) is hotly debated. Here we investigated PlGF isoforms 1 and 2 and present in vitro and in vivo evidence that PlGF-1, but not PlGF-2, can inhibit VEGF-induced permeability but only during a critical window post-VEGF exposure. PlGF-1 promotes VE-cadherin expression via the trans-activating Sp1 and Sp3 interaction with the VE-cadherin promoter and subsequently stabilizes transendothelial junctions, but only after activation of endothelial cells by VEGF. PlGF-1 regulates vascular permeability associated with the rapid localization of VE-cadherin to the plasma membrane and dephosphorylation of tyrosine residues that precedes changes observed in claudin 5 tyrosine phosphorylation and membrane localization. The critical window during which PlGF-1 exerts its effect on VEGF-induced permeability highlights the importance of the translational significance of this work in that PLGF-1 likely serves as an endogenous anti-permeability factor whose effectiveness is limited to a precise time point following vascular injury. Clinical approaches that would pattern nature's approach would thus limit treatments to precise intervals following injury and bring attention to use of agents only during therapeutic windows.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Additional Information: This article has been retracted. Please follow the links to the journal website for more information. Notice DOI: 10.1371/journal.pone.0210983
Publisher: Public Library of Science
ISSN: 1932-6203
Date of First Compliant Deposit: 30 March 2016
Last Modified: 31 Mar 2020 13:42

Citation Data

Cited 32 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics