Gallacher, John Edward, Elwood, Peter Creighton, Pickering, Janet Elizabeth, Bayer, Antony James, Fish, Mark and Ben-Shlomo, Yoav 2012. Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS). Journal of Epidemiology and Community Health 66 (10) , pp. 869-873. 10.1136/jech-2011-200314 |
Abstract
Background Benzodiazepine use is widespread in older people, although its benefit is uncertain. Aim To investigate the long-term effect of benzodiazepine use upon dementia risk. Methods A prospective cohort of men seen on five occasions over 22 years with full medication histories, repeat measures of cognitive function and a clinical diagnosis of dementia. Results Of 1134 men with complete data, 103 (9.1%) had been taking benzodiazepines regularly at one or more phases. These men showed a marked increased incidence of dementia (OR¼3.50, 95% CI 1.57 to 7.79, p¼0.002), which persisted despite adjustment for psychological distress and other covariates. Men exposed in earlier phases showed a greater association than more recent exposure, counter to what one would expect if this was due to reverse causation, though we failed to demonstrate a doseeresponse effect with drug duration. Conclusion The taking of benzodiazepines is associated with an increased risk of dementia.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine Systems Immunity Research Institute (SIURI) |
Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine |
Publisher: | BMJ Group |
ISSN: | 0143-005X |
Last Modified: | 08 Mar 2020 16:08 |
URI: | http://orca.cf.ac.uk/id/eprint/28821 |
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