Martin, Tracey Amanda, Mason, Malcolm David and Jiang, Wen Guo 2011. Tight junctions in cancer metastasis. Frontiers in Bioscience 16 (3) , pp. 898-936. 10.2741/3726 |
Official URL: http://dx.doi.org/10.2741/3726
Abstract
Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
Publisher: | Frontiers in Bioscence |
ISSN: | 1093-9946 |
Last Modified: | 05 Sep 2020 01:24 |
URI: | http://orca.cf.ac.uk/id/eprint/28847 |
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