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Reduced laterality as a trait marker of schizophrenia - evidence from structural and functional neuroimaging

Oertel, Viola, Knochel, Christian, Rotarska-Jagiela, Anna, Schonmeyer, Ralf, Lindner, Michael, van de Ven, Vincent, Haenschel, Corinna, Uhlhaas, Peter, Maurer, Konrad and Linden, David Edmund Johannes 2010. Reduced laterality as a trait marker of schizophrenia - evidence from structural and functional neuroimaging. Journal of Neuroscience 30 (6) , pp. 2289-2299. 10.1523/JNEUROSCI.4575-09.2010

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Abstract

Laterality is a characteristic principle of the organization of the brain systems for language, and reduced hemispheric asymmetry has been considered a risk factor for schizophrenia. Here we sought support for the risk factor hypothesis by investigating whether reduced asymmetry of temporal lobe structure and function is also present in unaffected relatives. Sixteen schizophrenia patients, 16 age-matched first-degree relatives, and 15 healthy controls underwent high-resolution three-dimensional anatomical imaging and functional magnetic resonance imaging during auditory stimulation. Both the overall auditory cortex and planum temporale volumes and the lateralization to the left hemisphere were markedly reduced in patients. The decrease of lateralization correlated with increased severity of symptoms. In addition, both the overall functional activation in response to auditory stimulation and its asymmetry were reduced in the patients. Relatives had intermediate values between patients and controls on both structural and functional measures. This study provides added support for the idea that reduced hemispheric asymmetry is a biological risk factor for schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Psychology
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Society for Neuroscience
ISSN: 0270-6474
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 03:54
URI: http://orca.cf.ac.uk/id/eprint/28870

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Cited 62 times in Web of Science. View in Web of Science.

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