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Neonatal plasma TSH - estimated upper reference intervals for diagnosis and follow up of congenital hypothyroidism

Evans, Carol, Neale, Sarah, Geen, John, Jones, Gareth, Mannings, Leanne, Trow, Sandra, Brain, Andrew, Nix, Arthur Barry John, Ellis, Richard, Hancock, Sian, Shine, Brian, Warner, Justin T., Gregory, John Welbourn and Moat, Stuart James 2011. Neonatal plasma TSH - estimated upper reference intervals for diagnosis and follow up of congenital hypothyroidism. Scandinavian Journal of Clinical & Laboratory Investigation 71 (5) , pp. 394-398. 10.3109/00365513.2011.575234

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Abstract

Age- and method-dependent plasma TSH reference intervals are essential for the diagnosis and management of congenital hypothyroidism. However, accurate reference intervals for plasma TSH have not been adequately defined due to the difficulties in obtaining samples from a healthy paediatric population. To overcome the difficulties in generating such intervals we estimated method-dependent plasma TSH upper-reference intervals by determining the blood spot TSH upper-reference interval from newborn blood spot TSH screening data (N = 10,697) and then derived method-dependent conversion factors for blood spot TSH to plasma TSH concentration from paired-blood spot and plasma TSH measurements. The upper reference interval for blood spot TSH of 3.04 mU/L was obtained from the 97.5th centile of the selected data. Using experimentally-derived conversion factors, estimates of plasma TSH upper reference intervals of 7.6, 6.3, 7.3, 8.3 and 6.5 mU/L were obtained for the Siemens Centaur, Abbott Architect, Roche Elecsys E170, Siemens Immulite 2000 and Beckman access HYPERsensitive TSH assays respectively. These estimated method-dependent plasma TSH upper reference intervals will be of great practical use to clinicians to diagnose and to follow up infants found to have increased blood spot TSH concentrations identified by Newborn Screening programmes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Uncontrolled Keywords: congenital hypothyroidism, thyroid stimulating hormone (TSH), reference ranges
Publisher: Informa Healthcare
ISSN: 0036-5513
Last Modified: 05 Nov 2019 04:09
URI: http://orca.cf.ac.uk/id/eprint/28896

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